ZORYL M2

COMPOSITION:

GLIMEPIRIDE 2MG

METFORMIN HYDROCHLORIDE IN PROLONGED RELEASE FORM 500MG

MANUFACTURED/MARKETED BY:

INTAS PHARMACEUTICALS LTD

RETURN POLICY: 

NON-RETURNABLE

EXPIRY DATE:

MAXIMUM ABOVE 3 MONTHS 

DESCRIPTION:

Composition & Form

Glimepiride 2 mg (sulfonylurea – stimulates insulin release)

Metformin 500 mg PR (biguanide – decreases hepatic glucose production and improves insulin sensitivity)

Zoryl  M 2 is a prolonged-release bilayer tablet, designed for once‑daily administration.

Indication

Approved for type 2 diabetes mellitus in adults, especially when single-agent therapy (metformin or a sulfonylurea) doesn’t achieve adequate glycemic control

Dosage & Administration

Once daily, to be taken with food to minimize gastrointestinal upset

Tablets should be swallowed whole, without crushing or chewing

Common Side Effects

Hypoglycemia: sweating, tremors, dizziness, headache—particularly if meals are missed or alcohol is consumed

Gastrointestinal complaints: nausea, vomiting, diarrhea, metallic taste, flatulence, abdominal discomfort

Weight gain may occur due to glimepiride

Vitamin B12 deficiency, especially with long-term metformin use

Rare/Serious Risks

Lactic acidosis (rare but serious, linked to metformin)—risk rises in kidney impairment, dehydration, heavy alcohol use; symptoms include muscle pain, difficulty breathing, dizziness

Allergic reactions: rashes or skin changes possible

Hematologic effects: anemia, possible visual disturbances or changes in blood counts

Contraindications

Not recommended for:

Type 1 diabetes or diabetic ketoacidosis

Severe renal or hepatic impairment

Pregnancy and breastfeeding

Patients with hypersensitivity to glimepiride or metformin 

Conditions like dehydration, severe infections, heart/lung failure, acute illness, shock, or prior exposure to iodinated contrast

Monitoring & Precautions

Monitor blood glucose regularly, and check kidney/liver function, vitamin B12, and full blood count periodically

Use caution in elderly, malnourished, or G6PD-deficient patients

Avoid abrupt discontinuation

Inform your doctor about upcoming surgeries, illnesses, or use of contrast agents

Summary Table

 Final Advice

Start and adjust Zoryl M 2 only under medical supervision. Take it with food at the same time every day, and always have a quick sugar source on hand. Monitor your blood sugar and periodic lab values closely.