ZORYL M1 FORTE

COMPOSITION:

GLIMEPIRIDE 1MG

METFORMIN HYDROCHLORIDE IN PROLONGED RELEASE FORM 1000MG

MANUFACTURED/MARKETED BY:

INTAS PHARMACEUTICALS LTD

RETURN POLICY: 

NON-RETURNABLE

EXPIRY DATE:

MAXIMUM ABOVE 3 MONTHS 

DESCRIPTION:

A combination medication containing glimepiride (1 mg) and metformin (1000 mg), used to help control blood sugar levels in adults with type 2 diabetes

How it works

Glimepiride (a sulfonylurea) stimulates insulin release from the pancreas.

Metformin (a biguanide) lowers liver glucose production, delays intestinal absorption, and increases insulin sensitivity

Uses

Prescribed alongside diet and exercise to treat type 2 diabetes when one drug alone isn’t sufficient

Dosage & Administration

Taken once daily with food, ideally with the evening or main meal.

Tablets should be swallowed whole — do not crush or chew

Side Effects

Common:

Low blood sugar (hypoglycemia): sweating, dizziness, headache, shaking

Nausea, diarrhea, stomach discomfort, metallic taste, upper respiratory infection, weight gain, headache

Serious but rare:

Lactic acidosis (especially if kidney disease, heavy alcohol use): symptoms include nausea, muscle pain, breathing difficulty, slow heartbeat

Decreased vitamin B12 with long-term use .

Precautions & Contraindications

Not suitable for:

Type 1 diabetes

Diabetic ketoacidosis

Severe kidney or liver impairment

Pregnancy and breastfeeding (unsafe or not recommended)

Use with caution in older adults, cardiovascular disease, before surgeries, or with other drugs that affect blood sugar. Kidney and liver functions should be monitored .

Drug & Lifestyle Interactions

Avoid alcohol: Increases risk of low blood sugar and lactic acidosis

Many drug interactions: e.g., antibiotics, steroids, anticoagulants, diuretics, and others may affect efficacy or risk profile .

Watch out for symptoms of hypoglycemia, especially when driving or operating machinery

Monitoring & Management

Regular blood glucose checks, periodic testing of kidney/liver function and blood counts.

Stay alert for symptoms of hypoglycemia and carry a quick sugar source.

Maintain a consistent diet, physical activity, and avoid skipping meals

Summary Table

🔍 What You Should Do

Take exactly as prescribed.

Do not stop abruptly—this may spike blood sugar.

Talk to your doctor if you experience excessive hypoglycemia, GI issues, or signs of lactic acidosis.

Bring up any changes in other medications or alcohol use.